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for three years to help manage her PCOS.Courtesy Allison Tuckman According to Dr. Melanie Cree, the Official Three Things You Don’t Mess With My Family My Freedom My German Shepherd Shirt in other words I will buy this director of the multidisciplinary PCOS clinic at the University of Colorado, women with PCOS often develop insulin resistance, which can turn into diabetes if left unchecked. The insulin resistance can also cause weight gain and make losing weight challenging, even with diet and exercise. Doctors often prescribe another diabetes drug, metformin, to help with PCOS-related insulin resistance, though the drug works in a different way than GLP-1 agonists. Tuckman tried metformin for several years, but said it stopped working for her, which is why her doctor suggested Ozempic. Cree is running a Phase 2/3 clinical trial of semaglutide for young women who have both PCOS and obesity. The pediatric endocrinologist is tracking the participants’ weight loss, hormone levels and menstrual cycle regularity to determine whether the drug really helps with the condition. But because losing weight in general can help with PCOS, Cree isn’t sure if semaglutide’s effects on PCOS are separate from its effects on weight. To help answer this question, she’s planning to take a close look at the hormonal and metabolic outcomes in any women on her trial who took semaglutide, but didn’t lose much weight. If the drug improves the hormone and metabolic effects of PCOS but doesn’t cause weight loss, then the drug will have had an independent benefit for PCOS, Cree said. “When it works, it works” Cree is also planning another, larger PCOS trial to look more closely at whether semaglutide increases ovulation among women with PCOS. Results from her current study are expected in the fall. Meanwhile, Cree, who also prescribes semaglutide to patients with diabetes and

obesity — many of whom also have PCOS — said the Official Three Things You Don’t Mess With My Family My Freedom My German Shepherd Shirt in other words I will buy this personal experiences she’s heard of have been revealing. “When it works, it works,” she said. Cree remembers one of her patients’ mothers crying during an appointment late last year. “She said, ‘You’ve given me my daughter back,’ and then everybody in the room was crying,” Cree said. “These medications are life-changing.” Dr. Rekha Kumar, an endocrinologist at Weill Cornell Medicine in New York City, cautioned that even if clinical trials do show a clear benefit, GLP-1 agonist drugs like Ozempic wouldn’t be a cure-all for women with PCOS: The symptoms can vary quite a bit, and not all women experience the metabolic symptoms most likely to benefit from GLP-1 agonists. The drugs are also much more expensive than existing medications that address insulin resistance like metformin. “GLP-1 agonists can be used in place of metformin if patients didn’t previously respond at all to metformin or if they did not tolerate it because of side effects,” Kumar said. Trials like Cree’s could help compile proof these drugs work for PCOS but, to secure FDA approval and widespread insurance coverage, the companies that make these drugs — in semaglutide’s case, Novo Nordisk — would need to step in and run a far larger and more expensive trial. Recommended HEALTH NEWS Skin moles that grow hair may offer

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