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alcohol use disorder by the Official Trans Rights Are Human Rights T-Shirt besides I will buy this end of the year, and expects to see a positive effect. But without the trials, there’s no proof. And, as both Leggio and Schacht acknowledged, without the drug, there are no trials. Like Cree with her PCOS trial, both Leggio and Schacht are concerned about having trouble securing the drug for their studies due to shortages. Novo Nordisk said in an email that it has no immediate plans to study semaglutide for alcohol use disorder. Leggio added that even when the supply issue resolves, it will still be important for a drug company to eventually take the reins of the research, as it would have the funding and resources to carry out a large-scale clinical trial. Drug companies step in for Alzheimer’s There’s one condition that’s piqued Novo Nordisk’s interest enough to warrant large-scale drug trials: Alzheimer’s. Novo Nordisk is running two clinical trials with nearly 4,000 people to find out whether semaglutide is better than a placebo at slowing cognitive decline in people with early Alzheimer’s. According to Dr. Leila Parand, a neurologist who treats patients with Alzheimer’s at UCLA Health, past research studies suggested these drugs can help prevent damage in brain blood vessels that can lead to Alzheimer’s. “They help preserve

nerve cells and expand the Official Trans Rights Are Human Rights T-Shirt besides I will buy this growth of branches of nerve cells and help with inflammation,” Parand said. If they work, the GLP-1 drugs would be a welcome addition to the limited treatment options for Alzheimer’s. FDA approves new Alzheimer’s drug JAN. 7, 202301:47 Parand’s medical center at UCLA is one of several hundred locations where patients can enroll in one of the Novo Nordisk clinical trials of semaglutide for early Alzheimer’s. Earlier this month, she had to close enrollment early since the trial filled up ahead of schedule. According to Parand, this, too, is thanks to the skyrocketing interest in these drugs, which led many people with early Alzheimer’s to learn about the trial. But any clear conclusions for all these potential uses of semaglutide are still years away. One of Novo Nordisk’s Alzheimer’s trials, launched in 2021, isn’t slated to end until 2026. Other questions that researchers are still trying to answer for diabetes and obesity hang in the air, too. Do people need to take GLP-1 drugs forever? What happens when they stop? What are the long-term side effects? “We just really don’t know,” Cree said “We don’t have the data, and there’s so much more to be learned.”Follow NBC HEALTH on Twitter & Facebook.

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