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Pediatric cancer doctors are sounding the Official I Cannot Be Held Responsible For My Actions T-shirt in other words I will buy this alarm about a growing shortage of chemotherapy drugs for children. The dwindling supplies add another layer to the ongoing cancer drug shortage crisis that’s left doctors scrambling and forced patients to make difficult choices about treatments since early February. The Biden administration has taken steps to address the crisis, in some cases successfully: Doctors say that shortages of two cancer drugs, carboplatin and cisplatin, have eased significantly in recent weeks. However, reports from children’s hospitals across the country are pointing to supply problems for two other chemotherapy drugs that are commonly used to treat pediatric cancers: vinblastine and dacarbazine. Another chemotherapy drug also often used in children, methotrexate, has been in short supply since March, and is still hard to come by. All three drugs are used for a range of cancers but, in children, vinblastine and dacarbazine are most commonly used to treat Hodgkin lymphoma. Methotrexate is the go-to drug for acute lymphoblastic leukemia, the most common cancer in children. The supply
issues mean doctors must substitute the Official I Cannot Be Held Responsible For My Actions T-shirt in other words I will buy this drugs with less effective alternatives or delay treatment until the drugs become available again. “It’s devastating,” said Dr. Doug Hawkins, chair of the Children’s Oncology Group, a national research organization. “Can you imagine that your child has been diagnosed with cancer, and you’re told, ‘We know how to treat this, so we have a 70% chance, an 80% chance, a 90% chance of curing your child with standard treatment, and Oh, by the way, we can’t get one of those standard treatments.’” ‘Not fixing the problem at large’ The Biden administration announced this month that the supplies of carboplatin and cisplatin have almost returned to pre-shortage levels, though the two drugs are still among the 15 listed as in shortage by the White House. Dr. Eleonora Teplinsky, a breast and gynecologic medical oncologist, said at her hospital in Ridgewood, New Jersey, that the supplies of carboplatin and cisplatin are “significantly better,” if not fully resolved. However, in recent weeks, her colleagues who treat blood cancers have expressed deep concerns about the availability of vinblastine. Blood cancers include leukemia and lymphoma. The American Society of Health-System Pharmacists, a group that tracks drug shortages, said it started to notice supply issues for vinblastine and dacarbazine this month. “What we’ve seen is that they’ve been able to fix individual shortages, but we’re still not fixing the problem at large,” Teplinsky, who heads the breast medical oncology team for Valley Health System, said of the federal government’s response to the drug shortages. In the absence of vinblastine, doctors in some cases may use a different drug, called vincristine, she said, but it can be less effective and comes with a different range of side effects. But in other cases, there are
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